Sweet proteins are a relatively unstudied class of sweet compounds that could serve as innovative sweeteners. Sweet proteins mediate the translocation of sugars across cell membranes so that they taste like sugar but digest like proteins.
There is not enough evidence to conclude whether or not sweet proteins are safe to consume regularly. However, inflammation was observed in clinical animal trials.
Metabolic Effects of the Sweet Protein MNEI as a Sweetener in Drinking Water. A Pilot Study of a High Fat Dietary Regimen in a Rodent Modelhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893535/
Structure, evolution and diverse physiological roles of SWEET sugar transporters in plantshttps://pubmed.ncbi.nlm.nih.gov/31030374/#:~:text=Sugars%20Will%20Eventually%20be%20Exported,of%20sugars%20across%20cell%20membranes.