Over consumption of fructose in this form is a major cause of heart disease, obesity, cancer, dementia, liver failure, tooth decay, and other diseases. Excessive added sugar intake is associated with adverse health conditions, including obesity, metabolic syndrome, and inflammatory diseases. Excessive sugar consumption may trigger neuroadaptations in the brain that decouple eating behavior from caloric needs and leads to compulsive overeating. The American Heart Association suggests an added-sugar limit of no more than 24 grams of sugar for most women and no more than 36 grams of sugar for most men each day.